Research
Discovery of novel drivers of axon degeneration
Neuron death and axon degeneration are tightly controlled processes. This project aims to identify new neuronally-enriched drivers of axon degeneration.
We hope to uncover novel therapeutic targets to treat chemotherapy-induced peripheral neuropathy without interfering with the drug’s effect on cancer.
We are doing this by combining state-of-the-art high content imaging and gRNA delivery into mature human neurons.
This project is aimed to treat the neurological side effects of patients who undergo treatment with microtubule-interacting drugs such as vincristine and placlitaxel (Taxol). These compounds are used to treat breast, prostate or ovarian cancer, as well as many other types of solid tumors.
CRISPRi screens of chemotherapy-induced neuron death
Not all chemotherapy agents drive neuron death in the same way.
By using whole genome CRISPRi screens we are identifying common and distinct pathways that cause neuron death.
We are also using this information to better understand how neuron death is regulated in other neurodegenerative conditions such as ALS or glaucoma.
Development of new inhibitors of neurodegeneration
We have a strong clinical focus. By applying what we learn in other projects, we are developing new ways to mitigate neurodegeneration in vivo and in vitro.
This project is really exciting and ongoing. We cant wait to share more with the community soon!