2024

ATF2 phosphorylation is essential for neuronal apoptosis, linking the DLK/LZK kinase cascade to JUN upregulation - Jorge Gomez-Deza, Matthew Nebiyou, Mor R. Alkaslasi, Lara H. El Touny, Anastasia L. Slavutsky, Nathan Ashby, Ken Cheng, Claire E. Le Pichon. BioRxiv doi: https://doi.org/10.1101/2023.09.27.559856doi.org/10.1101/2023.09.27.559856

DLK-dependent axonal mitochondrial fission drives degeneration following axotomy - Gómez-Deza J, Nebiyou M, Alkaslasi MR, Nadal-Nicolás FM, Somasundaran P, Slavutsky AL, Ward ME, Li W, Watkins TA, Le Pichon CE. Nat Commun. 2024 Dec 30;15(1):10806. doi: 10.1038/s41467-024-54982-9.

2023

Local production of reactive oxygen species drives vincristine-induced axon degeneration - Gomez-Deza J*, Slavutsky AL*, Nebiyou M, Le Pichon CE.Cell Death Dis. 2023 doi: 10.1038/s41419-023-06227-8.

ALS/ Graduate Student

Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies - Gomez-Deza J, Shaw CE. Book chapter - The molecular and Cellular Basis of Neurodegenerative diseases 2018. https://doi.org/10.1016/B978-0-12-811304-2.00005-5

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity - Lee YB, Baskaran P, Gomez-Deza J, Chen HJ, Nishimura AL, Smith BN, Troakes C, Adachi Y, Stepto A, Petrucelli L, Gallo JM, Hirth F, Rogelj B, Guthrie S, Shaw CE.Hum Mol Genet. 2017 doi: 10.1093/hmg/ddx350.

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration - Gomez-Deza J, Lee YB, Troakes C, Nolan M, Al-Sarraj S, Gallo JM, Shaw CE. Acta Neuropath. Commun. 2015 doi: 10.1186/s40478-015-0218-y.

Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic - Lee YB, Chen HJ, Peres JN, Gomez-Deza J, Attig J, Stalekar M, Troakes C, Nishimura AL, Scotter EL, Vance C, Adachi Y, Sardone V, Miller JW, Smith BN, Gallo JM, Ule J, Hirth F, Rogelj B, Houart C, Shaw CE. Cell Rep. doi: 10.1016/j.celrep.2013.10.049