Gómez-Deza Lab
Department of Cancer and Cellular Biology
Lewis Katz School of Medicine - Temple University
&
Fox Chase Cancer Center
Mission
Peripheral neuropathy and chronic pain are a common side effect of chemotherapy treatment for which there are no available treatments.
The Gómez-Deza Lab aims to understand how neurons are damaged in response to chemotherapy. However, our research is widely applicable to other neurodegenerative conditions such as glaucoma, traumatic brain injury (TBI) or Amyotrophic Lateral Sclerosis (ALS).
To do this, we employ a wide range of molecular and biochemical techniques, including iPSC differentiation into human neurons, whole genome CRISPR interference screens, RNAseq, CRISPR knock-ins/ knock-outs, and advanced microscopy.
The lab has a strong clinical focus. We are deeply interested in uncovering new molecular mechanisms that drive axon degeneration and neuron death to develop novel therapeutic strategies.
Our mission is also to educate and train the next generation of scientists by fostering a safe, innovative, fun and diverse environment that empowers individuals to reach their full potential. We value mental well-being, maintain a healthy work-life balance, and welcome everyone to our team.
Research questions
Discovery of novel drivers of axon degeneration
Neuron death and axon degeneration are tightly controlled processes. This project aims to identify new neuronally-enriched drivers of axon degeneration.
CRISPRi screens of chemotherapy-induced neuron death
Not all chemotherapy agents drive neuron death in the same way. By using whole genome CRISPRi screens we are identifying common and distinct pathways that cause neuron death.
Development of new inhibitors of neurodegeneration
We have a strong clinical focus. By applying what we learn in other projects, we are developing new ways to mitigate neurodegeneration in vivo and in vitro
We are recruiting!
We have a postdoc position available (see description below):
If you're interested or know anyone who might be, please send us an email:
Postdoctoral Fellow
The Gomez-Deza Lab is looking for an ambitious and productive Post-Doctoral Fellow to join the team.
Recent and soon-to graduate candidates with a Ph.D. degree from life science related fields and with record of publications are encouraged to apply.
Our team works on understanding the molecular mechanisms by which human neurons degenerate in response to chemotherapy treatment. However, our research is widely applicable to other neurodegenerative conditions such as glaucoma, traumatic brain injury or Amyotrophic Lateral Sclerosis (ALS). To do this we employ a wide range of molecular and biochemical techniques including iPSC differentiation into human neurons, whole genome CRISPR interference screens, RNAseq, CRISPR knock-ins/ knock-outs and advanced microscopy. We are looking for a candidate with a strong background in biochemistry and molecular biology. Experience in neuroscience and iPSCs is desired but not required.
This is a unique opportunity to engage in groundbreaking research with the potential to significantly impact the treatment of neuropathic pain during and after cancer treatment.
The position will be a dual appointment between Temple University and the Fox Chase Cancer center, and is fully funded for three years. Health insurance, annual leave and VISA processing is included as part of the position.
If you are interested send your CV and the contact details of 3 references to jorge.gomez-deza@temple.edu